Principal PK/PD Scientist – Respiratory

Our client, a leading global biopharmaceutical company, is seeking a Principal PK/PD Scientist to provide scientific leadership across a diverse respiratory development portfolio. The successful candidate will leverage advanced pharmacometric approaches to support critical decision-making, optimize dose selection, and drive model-informed drug development across innovative respiratory programs.

Key Responsibilities

• Lead the design, development, and application of PK/PD and pharmacometric analyses across respiratory assets.
• Develop and implement model-informed drug development (MIDD) strategies to support clinical development and regulatory decision-making.
• Conduct and oversee population PK, exposure-response, dose optimization, and simulation analyses.
• Collaborate closely with Clinical Pharmacology, Translational Medicine, Clinical Development, Biostatistics, Regulatory Affairs, and other cross-functional teams.
• Provide quantitative insights that shape program strategy and portfolio decisions.
• Contribute to regulatory submissions, briefing documents, and interactions with global health authorities.
• Drive scientific innovation through the application of advanced modelling and simulation techniques.
• Mentor junior scientists and contribute to the development of quantitative sciences capabilities across the organization.

What you'll need

• Significant pharmaceutical, biotechnology, or CRO industry experience.
• Extensive expertise in PK/PD modelling, population pharmacokinetics, exposure-response analysis, and model-informed drug development.
• Strong respiratory therapeutic area experience, including asthma, COPD, severe asthma, pulmonary fibrosis, chronic cough, or related respiratory indications.
• Advanced proficiency with NONMEM, Monolix, R, Phoenix NLME, or equivalent pharmacometric software.
• Demonstrated ability to influence development strategy and communicate complex quantitative findings to senior stakeholders.
• Experience supporting multidisciplinary global development teams.