Principle Scientist - Translational Research

(Neurodegeneration/Renal Disease)

Barrington James is partnering with a leading biopharmaceutical organization to find a skilled Principal Scientist for their Translational Unit. This lab-based role will focus on Neurodegeneration or Renal Disease, bridging the gap between preclinical research and early clinical studies through translational assays in human-derived cells, tissues, and biofluids.
Key Responsibilities:

• Design and execute laboratory experiments to drive scientific understanding and support drug discovery in neurodegeneration or renal disease.
• Lead the identification, validation, and development of clinical biomarkers and deployable biomarker assays.
• Apply advanced laboratory techniques including ELISA, flow cytometry, gene/protein expression analysis and proteomics.
• Troubleshoot assays and collaborate with cross-functional teams to ensure robust study designs.
• Ensure accurate, detailed lab records and compliance with data integrity and safety protocols.

• PhD in a relevant scientific discipline (e.g., Molecular Biology, Genetics, Immunology, etc.).
• 3-5+ years of experience in translational research and biomarker development.
• Expertise in handling primary human cells and performing laboratory techniques such as ELISA, flow cytometry, and gene expression analysis.
• Experience in either neurodegenerative diseases or renal diseases.

• Strong problem-solving abilities and capability to critically analyse scientific data.
• Excellent communication skills, both written and verbal, with the ability to present complex data clearly to internal and external stakeholders.
• Ability to manage multiple priorities, meeting deadlines while maintaining high-performance standards.
• Independent and collaborative, with a proven track record of defining strategic approaches to research goals.

• Design and execute laboratory experiments to drive scientific understanding and support drug discovery in neurodegeneration or renal disease.
• Lead the identification, validation, and development of clinical biomarkers and deployable biomarker assays.
• Apply advanced laboratory techniques including ELISA, flow cytometry, gene/protein expression analysis and proteomics.
• Troubleshoot assays and collaborate with cross-functional teams to ensure robust study designs.
• Ensure accurate, detailed lab records and compliance with data integrity and safety protocols.

• PhD in a relevant scientific discipline (e.g., Molecular Biology, Genetics, Immunology, etc.).
• 3-5+ years of experience in translational research and biomarker development.
• Expertise in handling primary human cells and performing laboratory techniques such as ELISA, flow cytometry, and gene expression analysis.
• Experience in either neurodegenerative diseases or renal diseases.

• Strong problem-solving abilities and capability to critically analyse scientific data.
• Excellent communication skills, both written and verbal, with the ability to present complex data clearly to internal and external stakeholders.
• Ability to manage multiple priorities, meeting deadlines while maintaining high-performance standards.
• Independent and collaborative, with a proven track record of defining strategic approaches to research goals.