Principle Statistician Role

Principal Statistician – Evidence Synthesis & HTA

Location: Oxfordshire or London
Sector: HEOR / Evidence Synthesis / HTA
Type: Permanent, full-time

Our client is seeking a Principal Statistician to lead complex evidence-synthesis programmes and guide statistical strategy across high-impact HTA and market access projects. This role offers substantial influence, technical leadership, and the opportunity to shape methodologies within a collaborative, methodologically focused team.

The Role

As a Principal Statistician, you will own the design, delivery, and interpretation of statistical components across multiple evidence-synthesis and HTA projects. You will partner closely with multidisciplinary teams while providing direction and mentorship for developing statisticians.

Key responsibilities include:

• Designing statistical analysis plans and feasibility assessments for advanced evidence-synthesis challenges.

• Coding and running analyses including pairwise meta-analysis, NMAs (including time-varying survival models), MAIC/PAIC, and individual patient data analyses.

• Overseeing quality control processes to ensure methodological rigour and reproducibility.

• Communicating complex statistical results clearly to clients and cross-functional teams.

• Leading contributions to proposals, pitch presentations, and development of internal methodologies, SOPs, and QC frameworks.

• Providing technical leadership, coaching, and mentorship to junior and mid-level statisticians.

About You

You bring depth of experience in evidence synthesis and thrive in roles that blend analytical excellence, leadership, and intellectual ownership. You enjoy shaping projects, influencing decision-making, and raising the statistical bar within a team.

Essential experience:

• Master’s degree or PhD in a quantitative discipline.

• Significant experience leading evidence-synthesis statistical work (meta-analysis, NMA, indirect comparisons).

• Proficiency in R, with familiarity in Bayesian approaches (e.g., BUGS).

• Strong track record in HTA-focused analyses and interpreting results for health economic models and submissions.

• Experience leading or mentoring statisticians and influencing analytical approaches.

• Clear and confident communication of complex statistical concepts to diverse audiences.

Desirable:

• Experience with advanced NMA developments (e.g., ML-NMR).

• Experience delivering training or statistical learning initiatives.

• Consultancy experience managing multiple projects simultaneously.

What’s on Offer

You’ll join a supportive, engaging environment where quality, curiosity, and development are central. Expect:

• A flexible working culture with genuine autonomy.

• Regular interaction with senior leadership and the chance to shape internal methodologies.

• Broad exposure across therapeutic areas and diverse HTA-focused projects.

• The influence and visibility expected of a true Principal-level role.