Modelling and Simulation Pharmacometrician

Senior Pharmacometrician (PBPK & Pre/Clinical Development)
Remote – UK / Europe

Barrington James is partnering with a rapidly growing Quantitative Pharmacology & Data Science CRO to appoint a Senior Pharmacometrician. This organisation partners with biotech and pharma companies to deliver model-informed drug development strategies across discovery, translational, and clinical phases.

This is a high-impact, client-facing role for an experienced modeller with deep expertise in PBPK, PK/PD, and clinical trial modelling, looking to influence decision-making across diverse therapeutic areas.

🔬 The Role
As a senior member of the modelling team, you will lead and deliver complex pharmacometric projects, working at the interface of biology, data science, and clinical strategy.

Key Responsibilities:
• Lead development of PBPK, PK/PD, and population PK models to support drug development decisions
• Design and execute modelling strategies for clinical trials and translational studies
• Analyse and interpret preclinical and clinical datasets, including NCA
• Apply modelling to inform dose selection, trial design, and regulatory strategy
• Translate complex quantitative outputs into clear, actionable insights for clients
• Contribute to regulatory submissions and interactions
• Lead client engagements, presentations, and technical reporting
• Support business development activities, proposals, and scientific discussions

Requirements

Essential:
• PhD (or MSc with significant experience) in Pharmacokinetics, Pharmacology, Bioengineering, or a related quantitative discipline
• 4–8+ years’ experience in pharmacometrics within industry or consultancy
• Proven expertise in PBPK modelling and clinical pharmacology
• Strong experience developing models to support clinical trial design and analysis
• Proficiency in R and industry-standard modelling tools
• Excellent communication skills with experience in client-facing roles
• Eligibility to work in the UK or Europe

Desirable:
• Experience with platforms such as GastroPlus, Simcyp, PK-Sim, Monolix, or SimBiology
• Background in oncology or complex disease modelling
• Experience supporting regulatory filings (e.g., IND, NDA, MAA)
• Track record of leading projects or mentoring junior scientists